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KMID : 0370019900040000003
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Chung-Ang Journal of Pharmacal Sciences
1990 Volume.4 No. 0 p.3 ~ p.14
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Biopharmaceutical Studies on the intestinal Absorption of Chinese Drugs
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Abstract
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The interaction of bezoar on the small intestinal absorption of baicalin in the Scutellariae Radix were studied using Schanker´s loop circulation method in comparison with dissolution rate and partition coefficient.
The results obtained are as follows :
1. Dissolution rate of baicalin in the Scutellariae Radix approached to plateau on 60 minutes. 2. Absorption rate of baicalin in the Scutellaria radix in the small intesinal tract was increased within 90 minutes by coexistence of bezoar fractions but not influenced after 90 minutes.
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